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Asthmatic Why is disease more nightly fit? PDF Print E-mail

 

BronchusAsthmaticThe patient often is in nightly to early morning fit or aggravate. Think at present, nightlyAsthmaticFit or aggravate have important sense, and will nightlyAsthmaticFit frequency discretion serves asAsthmaticOne of judgement index of illness weight. Additional, study the result still shows: Everyday peak value of expiratory velocity of flow (Pefr) is fluctuant and remarkable person incidental sudden death.

 

 

NightlyAsthmaticFit characteristic and rule are:

(1) model is nightlyAsthmaticEarly morning arrives in the middle of the night after fit time is, some patients do not have a symptom almost by day, be in only nightly fit, or expression is nightlyAsthmaticAggravate.

(The expression when 2) breaks out is breathing difficulty, bosom sends hold back, cough, patient constant because breath, bosom hair is tightened and wake, consequentlyMorpheusOften be disturbed, mondayish by day lack of power.

(3) is major nightlyAsthmaticHappen atMorpheusThe 2nd phase, be in more when fit move eye period quickly.

NightlyAsthmatichair life reason is more complex, division of breath of hospital of people of Beijing medical university thinks to Professor Quan Ying, likelihood and the following mechanism concern:

(Because 1) is nightlyMorpheusSympathetic is restrained when, and the parasympathetic nerve is excited, AsthmaticIn patient bloodTeaPhenolic amine secretes level and make water inTeaThe keep under control of section of day and night that phenolic amine excretes horizontal day and night to cut law and Pefr is consistent, both show remarkable positive to close. Contrary, level of amine of the organization in nightly blood relatively lift significantly by day, show negative to close with Pefr. Somebody observes, AsthmaticThe patient turns to work for evening shift, rest by day andMorpheusWhen, behave for by dayMorpheusThe Pefr after waking is reduced. Consequently nightlyAsthmaticThe likelihood is main withMorpheusReach lie about.

(Temperature of 2) normal human body is put in law of section of day and night, fluctuant extent is 1.1 Celsius inside one day and night, early morning 2 ~ 4 when temperature lowest. AsthmaticTemperature of patient before dawn drops extent is more than healthy person apparently, temperature drops to be able to be caused to 0.7 CelsiusAsthmaticThe patient's bronchus is contractive. Accordingly, thinking to enrage contractive likelihood at present is nightly happenAsthmaticone of mechanism.

(Distributing with medicine inside 3)24 hour inhomogenous, use drug by day namely and at night need not medicine, the haemal chroma that brings about the nightly medicaments that make the same score asthma drops.

(The cleared and mucous function of system of cilium of 4) spirit way also is put in law of section of day and night, nightly cilium motion is abate, mucous and cleared speed slows inside spirit way, make more allergic sources are reached mucous accumulative inside spirit way, also can accentuate spirit way block.

(5) is inspiratory in the evening indoor reach the allergen on the bed, or inspiratory by day allergen, produce the late reaction that send a gender, all can behave for nightlyAsthmatic.

(6)AsthmaticLevel of the cortin in patient plasma also has law of apparent section of day and night, nightly its level is reduced, agree with Pefr section law.

(7) is nightly smooth lie a countercurrent of canal of incidental stomach deadbeat, this also is hurried hair is nightlyAsthmaticA main factor.

(Recent research shows 8) , AsthmaticSpirit way reactivity of the patient also is put in law of section of clear day and night, reactivity is inferior by day, nightly reactivity is apparent heighten, increase to all sorts of exciting reaction consequently.

Anyhow, causeAsthmaticThe mechanism of nightly fit or aggravate is more complex, probable it is the result that collaboration of a variety of element put together use.

 
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